Rats and Morphine: A Big Surprise


One of the great aspects of my research into the process of addiction with relation to cytochromes in rats is that it is very new research, and very few  others have ventured into such areas of understanding. As I have come to realize in the past week is that this is more of a curse than a blessing. After many weeks of extensive research on the assumption that mice, like humans have CYP3A4, 2B6, and 2D6, I have come to the realization, that it is not known in the world of science whether mice have these specific cytochromes. In fact my research is so groundbreaking, it is impossible to even find the names of the cytochromes involved in drug metabolism in mice. This has forced me and my colleague to an academic standstill. Without this knowledge, moving forwards is impossible, as any action with regards to cytochromes at this point requires a large amount of money, and the future of that investment would be highly uncertain. If the cytochromes are present, then there is the possibility that a purchased antibody wouldn’t be reactive with the mouse version, and if there is no cytochrome, then we will have no way of knowing if they are present or not. From this point on, actions are unclear, but I will meet with my colleague this week to try and discuss solutions and how to move forwards with our goals.

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